Cancer is a genetic disease caused by changes to genes. Approximately 5–10% of cancers are due to inherited genetic defects of cancer predisposition genes from a person's parents. Genetic tests can help estimate risks of developing cancer in one’s lifetime. Variants can be classified into pathogenic variants, benign variants, variants of uncertain significance and so on. Pathogenic variants may increase lifetime risks of cancer.
Individuals suspected of having cancer risk, he/she will have the time to work with healthcare provider or physicians to make choices that feel right for him/her:
For individuals who have elevated colon cancer risk, colonoscopies should be performed earlier and more frequently.
Some common medications have been shown to reduce the risk of cancers. For example, aspirin can reduce the risk of hereditary colon cancer.
Prevention usually involves surgical removal of the at-risk tissue, for example, conducting bilateral risk-reduction mastectomy (RRM) deceased risk of developing breast cancer in known BRCA1/2 mutation carriers.
There are more than 200 different types of hereditary cancer syndrome. CloudHealth provides different combinations of genetic tests for different types of hereditary cancer syndrome with a total of 55 genes. Certain genetic test can be selected according to personal and family history.
|BRCA1/2 Breast cancer and ovarian cancer||BRCA1、BRCA2|
|gynecological oncology (breast cancer/ovarian cancer/ endometrial cancer) with 26 genes||BRCA1、BRCA2、PTEN、TP53、CDH1、ATM、BRIP1、CHEK2、MSH2、MLH1、MSH6、PMS2、EPCAM、NBN、NF1、PALB2、RAD51C、RAD51D、STK11、BARD1、FANCC、MRE11A、MUTYH、XRCC2、SMARCA、RAD50|
|Colorectal cancer with 11 genes||APC、BMPR1A、EPCAM、MLH1、MSH2、MSH6、MUTYH、PMS2、PTEN、SMAD4、TP53|
|Gastric cancer with CDH1 test||CDH1|
|Colorectal cancer and gastric cancer with 24 genes||APC、ATM、AXIN2、BLM、BMPR1A、CHEK2、EPCAM、EXO1、GALNT12、GREM1、LH3、MLH1、MSH2、MSH6、MUTYH、NTHL1、PMS1、PMS2、POLD1、POLE、PTEN、SMAD4、STK11、TP53|
|Pancreatic cancer with 18 genes||BRCA1、BRCA2、PALB2、FANCC、FANCG、ATM、PRSS1、SPINK1、CTFR、MLH1、MSH2、MSH6、PMS2、EPCAM、STK11、VHL、CDKN2A、CDK4|
|Melanoma with 5 genes||CDKN2A、CDK4、TP53、PTEN、BRCA2|
|Prostate cancer with 5 genes||BRCA2、BRCA1、CHEK2、TP53、NBN|
|Other cancers (kidney cancer, thyroid cancer, retinoblastoma and so on) with 13 genes||MEN2a、MEN2b、VHL、TSC1、TSC2、FLCN、MET、FH、RB1、TP53、PTEN、CHEK2、MEN1|
EDTA anticoagulative tube for 3-5 mL peripheral blood; mouth swabs for oral mucosa cells; saliva collection for saliva.
Turnaround time from sample receipt to report issue is 25 days.
Issuing report and providing genetic counseling.
The target region covers all coding exons of BRCA1 and BRCA2 genes
Deep sequencing and rigorous process
Assessment of variants according to international authoritative database
1. Patients with cancer
2. Individuals from a family with hereditary cancer
3. Individuals who cares cancer risk